PMID

Data

Article Title

Organization

Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.

Sichuan University and Collaborative Innovation Center For Biotherapy

Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).

Icahn School of Medicine At Mount Sinai

Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.

University of California

A one-pot synthesis and biological activity of ageladine A and analogues.

Macquarie University

Comprehensive analysis of kinase inhibitor selectivity.

Ambit Biosciences

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

Ambit Biosciences

The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance.

Guangzhou University of Chinese Medicine

Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions.

Sichuan University

The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush.

Baylor College of Medicine

Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.

Beijing Normal University

Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer.

Shenyang Pharmaceutical University

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.

Institute

Discovery of BAY-985, a Highly Selective TBK1/IKK? Inhibitor.

Bayer

Discovery of 4

TBA

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.

University of Florida

Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.

Takeda Pharmaceutical

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy.

China Pharmaceutical University

Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment.

Sichuan University

HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.

The Scripps Research Institute

UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target.

Sichuan Universitt China Hospital